Endothelial dysfunction following coronary artery bypass grafting : Influence of patient and procedural factors.
Herz
; 45(1): 86-94, 2020 Feb.
Article
em En
| MEDLINE
| ID: mdl-29774399
ABSTRACT
BACKGROUND:
Angiopoietin-2 (Angpt2) mediates endothelial dysfunction (ED) following coronary artery bypass grafting (CABG). Its triggers are, however, poorly understood.METHODS:
We examined the time course of ED beyond the early phase of postoperative recovery in 75 patients following CABG with a special focus on different cardiopulmonary bypass (CPB) modes as potential triggers of Angpt2 release.RESULTS:
Nine patients (12.0%) underwent off-pump coronary artery bypass (OPCAB), 31 patients (41.3%) received minimized extracorporeal circulation (MECC), and 35 patients (46.6%) were operated on with (conventional) CPB. Angpt2 levels steadily increased across the observation period (1.7 [1.4-2.1] to 3.4 [2.5-6.1]â¯ng/ml, pâ¯< 0.001). Angpt2 levels did not differ between the MECC and CPB groups (pâ¯= 0.564). There was no difference between MECC and CPB patients regarding net fluid balance (pâ¯= 0.821) and other surrogate markers of postoperative ED. The magnitude of Angpt-2 increase correlated more strongly with baseline Creactive protein (râ¯= 0.459, pâ¯< 0.001) than with any other parameter. Hospital length of stay correlated more strongly with baseline Angpt2 levels (râ¯= 0.512, pâ¯= 0.005) than with follow-up Angpt2 levels and appeared not to be influenced by CPB mode (pâ¯= 0.428).CONCLUSION:
CABG is associated with prolonged ED, which is determined by the patient's preoperative inflammatory state rather than by CPB modifications.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
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Ponte Cardiopulmonar
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Ponte de Artéria Coronária
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Ponte de Artéria Coronária sem Circulação Extracorpórea
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Herz
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha