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Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.
Lu, Tianbao; Schubert, Carsten; Cummings, Maxwell D; Bignan, Gilles; Connolly, Peter J; Smans, Karine; Ludovici, Donald; Parker, Michael H; Meyer, Christophe; Rocaboy, Christian; Alexander, Richard; Grasberger, Bruce; De Breucker, Sabine; Esser, Norbert; Fraiponts, Erwin; Gilissen, Ron; Janssens, Boudewijn; Peeters, Danielle; Van Nuffel, Luc; Vermeulen, Peter; Bischoff, James; Meerpoel, Lieven.
Afiliação
  • Lu T; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, USA. Electronic address: tlu3@its.jnj.com.
  • Schubert C; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, USA.
  • Cummings MD; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, USA.
  • Bignan G; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, USA.
  • Connolly PJ; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, USA.
  • Smans K; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Ludovici D; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, USA.
  • Parker MH; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, USA.
  • Meyer C; Janssen Research & Development, CS10615, Campus de Maigremont 27106 Val de Reuil, France.
  • Rocaboy C; Villapharma Research, Parque Tecnologico de Fuente Alamo, Carretera El Estrecho-Lobosillo, 30320 Murcia, Spain.
  • Alexander R; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, USA.
  • Grasberger B; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, USA.
  • De Breucker S; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Esser N; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Fraiponts E; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Gilissen R; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Janssens B; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Peeters D; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Van Nuffel L; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Vermeulen P; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Bischoff J; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, PA 19477, USA.
  • Meerpoel L; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
Bioorg Med Chem Lett ; 28(12): 2159-2164, 2018 07 01.
Article em En | MEDLINE | ID: mdl-29779975
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores Enzimáticos / Ácido Graxo Sintase Tipo I / Imidazóis / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Inibidores Enzimáticos / Ácido Graxo Sintase Tipo I / Imidazóis / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article