Tricyclic-induced mania and MHPG excretion.
Psychiatry Res
; 1(1): 93-9, 1979 Jul.
Article
em En
| MEDLINE
| ID: mdl-298343
ABSTRACT
In order to evaluate the presumed involvement of altered noradrenergic receptor sensitivity in the switch process from depression into mania, we explored the relationship between pretreatment 3-methoxy-4-hydroxy-phenylglycol (MHPG) and tricyclic-induced mania or hypomania in bipolar depressed patients. Within the group of patients developing mania or hypomania on tricyclics, there was a strong positive correlation between pretreatment 24-hour urinary MHPG and the latency of onset of the episode. This finding is consistent with both the reported differences in MHPG excretion between unipolar and bipolar patients and the postulated noradrenergic involvement in the switch process.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno Bipolar
/
Transtornos Psicóticos Afetivos
/
Glicóis
/
Metoxi-Hidroxifenilglicol
/
Antidepressivos Tricíclicos
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Psychiatry Res
Ano de publicação:
1979
Tipo de documento:
Article