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Highly Attenuated Infection With a Vpr-Deleted Molecular Clone of Human Immunodeficiency Virus-1.
Ali, Ayub; Ng, Hwee L; Blankson, Joel N; Burton, Dennis R; Buckheit, Robert W; Moldt, Brian; Fulcher, Jennifer A; Ibarrondo, F Javier; Anton, Peter A; Yang, Otto O.
Afiliação
  • Ali A; Department of Medicine, David Geffen School of Medicine, University of California Los Angeles.
  • Ng HL; UCLA AIDS Institute, University of California Los Angeles, Baltimore, Maryland.
  • Blankson JN; Department of Medicine, David Geffen School of Medicine, University of California Los Angeles.
  • Burton DR; UCLA AIDS Institute, University of California Los Angeles, Baltimore, Maryland.
  • Buckheit RW; Center for AIDS Research, Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland.
  • Moldt B; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, California.
  • Fulcher JA; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, California.
  • Ibarrondo FJ; Center for AIDS Research, Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland.
  • Anton PA; Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, California.
  • Yang OO; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, California.
J Infect Dis ; 218(9): 1447-1452, 2018 09 22.
Article em En | MEDLINE | ID: mdl-29878133
ABSTRACT
A 48-year-old woman was infected with a vpr-defective human immunodeficiency virus (HIV)-1 molecular clone. Seroconversion was markedly delayed, and without treatment she had durably suppressed viremia and normal T-cell levels. Neutralizing antibody and CD8+ T-cell immune responses against HIV-1 were unremarkable. Viral sequences confirmed the source but evolved defective nef, suggesting an unknown mechanistic link to vpr. There were subtle qualitative defects in T and B cells. To our knowledge, this is the only case of human infection with a characterized defective HIV-1 molecular clone, which furthermore recapitulated live-attenuated vaccination in macaque models of HIV-1 vaccine research.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Atenuadas / Infecções por HIV / HIV-1 / Vacinas contra a AIDS / Produtos do Gene vpr Tipo de estudo: Prognostic_studies / Qualitative_research Limite: Female / Humans / Middle aged Idioma: En Revista: J Infect Dis Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Atenuadas / Infecções por HIV / HIV-1 / Vacinas contra a AIDS / Produtos do Gene vpr Tipo de estudo: Prognostic_studies / Qualitative_research Limite: Female / Humans / Middle aged Idioma: En Revista: J Infect Dis Ano de publicação: 2018 Tipo de documento: Article