Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes.
Biochimie
; 151: 119-127, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29890205
ABSTRACT
A series of phosphonic acid analogues of phenylglycine variously substituted in phenyl ring have been synthesized and evaluated for their inhibitory activity towards potato l-phenylalanine ammonia lyase. Most of the compounds appeared to act as moderate (micromolar) inhibitors of the enzyme. Analysis of their binding performed using molecular modeling have shown that they might be bound either in active site of the enzyme or in the non-physiologic site. The latter one is located in adjoining deep site nearby the to the entrance channel for substrate into active site.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilalanina Amônia-Liase
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Ácidos Fosforosos
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Solanum tuberosum
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Inibidores Enzimáticos
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Glicina
Idioma:
En
Revista:
Biochimie
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Polônia