Shelterin differentially respond to oxidative stress induced by TiO<sub>2</sub>-NPs and regulate telomere length in human hepatocytes and hepatocarcinoma cells in vitro.

Wang, Han; Ni, Juan; Guo, Xihan; Zhou, Tao; Ma, Xiaoling; Xue, Jinglun; Wang, Xu

Shelterin differentially respond to oxidative stress induced by TiO₂-NPs and regulate telomere length in human hepatocytes and hepatocarcinoma cells in vitro.

Wang, Han; Ni, Juan; Guo, Xihan; Zhou, Tao; Ma, Xiaoling; Xue, Jinglun; Wang, Xu.

Afiliação

Wang H; School of Life Sciences, Yunnan Normal University, Kunming, Yunnan, 650500, China.
Ni J; School of Life Sciences, Yunnan Normal University, Kunming, Yunnan, 650500, China; Engineering Research Center of Sustainable Development and Utilization of Biomass Energy, Ministry of Education, Kunming, Yunnan, 650500, China.
Guo X; School of Life Sciences, Yunnan Normal University, Kunming, Yunnan, 650500, China; Engineering Research Center of Sustainable Development and Utilization of Biomass Energy, Ministry of Education, Kunming, Yunnan, 650500, China.
Zhou T; School of Life Sciences, Yunnan Normal University, Kunming, Yunnan, 650500, China; Engineering Research Center of Sustainable Development and Utilization of Biomass Energy, Ministry of Education, Kunming, Yunnan, 650500, China.
Ma X; Shanghai Sanyu China Gene Science & Technology CO., Ltd., Shanghai, 200433, China.
Xue J; State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, 200433, China.
Wang X; School of Life Sciences, Yunnan Normal University, Kunming, Yunnan, 650500, China; Engineering Research Center of Sustainable Development and Utilization of Biomass Energy, Ministry of Education, Kunming, Yunnan, 650500, China. Electronic address: wangxu@fudan.edu.cn.

Biochem Biophys Res Commun ; 503(2): 697-702, 2018 09 05.

Article em En | MEDLINE | ID: mdl-29909006

Assuntos

Hepatócitos/metabolismo; Neoplasias Hepáticas/metabolismo; Nanopartículas/efeitos adversos; Estresse Oxidativo; Proteínas de Ligação a Telômeros/metabolismo; Telômero/metabolismo; Titânio/efeitos adversos; Linhagem Celular; Linhagem Celular Tumoral; Instabilidade Cromossômica; Regulação para Baixo; Hepatócitos/patologia; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patologia; Complexo Shelterina; Telômero/patologia; Encurtamento do Telômero; Proteínas de Ligação a Telômeros/genética; Regulação para Cima

Palavras-chave

Hepatocytes; Oxidative stress; Shelterin; Telomere length; TiO(2-)NPs

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Titânio / Telômero / Estresse Oxidativo / Hepatócitos / Proteínas de Ligação a Telômeros / Nanopartículas / Neoplasias Hepáticas Limite: Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google