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Coactivator condensation at super-enhancers links phase separation and gene control.
Sabari, Benjamin R; Dall'Agnese, Alessandra; Boija, Ann; Klein, Isaac A; Coffey, Eliot L; Shrinivas, Krishna; Abraham, Brian J; Hannett, Nancy M; Zamudio, Alicia V; Manteiga, John C; Li, Charles H; Guo, Yang E; Day, Daniel S; Schuijers, Jurian; Vasile, Eliza; Malik, Sohail; Hnisz, Denes; Lee, Tong Ihn; Cisse, Ibrahim I; Roeder, Robert G; Sharp, Phillip A; Chakraborty, Arup K; Young, Richard A.
Afiliação
  • Sabari BR; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Dall'Agnese A; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Boija A; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Klein IA; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Coffey EL; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
  • Shrinivas K; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Abraham BJ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Hannett NM; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Zamudio AV; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Manteiga JC; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Li CH; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Guo YE; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Day DS; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Schuijers J; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Vasile E; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Malik S; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Hnisz D; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Lee TI; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Cisse II; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Roeder RG; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Sharp PA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Chakraborty AK; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
  • Young RA; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
Science ; 361(6400)2018 07 27.
Article em En | MEDLINE | ID: mdl-29930091
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Transativadores / Regulação da Expressão Gênica / Elementos Facilitadores Genéticos / Subunidade 1 do Complexo Mediador / Proteínas Intrinsicamente Desordenadas Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Transativadores / Regulação da Expressão Gênica / Elementos Facilitadores Genéticos / Subunidade 1 do Complexo Mediador / Proteínas Intrinsicamente Desordenadas Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos