Reactive oxygen species in cancer stem cells of head and neck squamous cancer.
Semin Cancer Biol
; 53: 248-257, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-29935313
ABSTRACT
One of the greatest challenges in systemic treatment of head and neck squamous cell carcinoma (HNSCC) is a small tumor cell population, namely, cancer stem-like cells (CSC). CSC can regenerate and maintain a heterogenic tumor by their self-renewal capacity. Their potential ability to be more resistant to and survival after chemo- and radiation therapy was also identified. Further studies have shown that reactive oxygen species (ROS) contribute to this CSC-associated resistance. In this review, we focus on the current knowledge of HNSCC-CSC, with regard to ROS as a possible and novel therapeutic approach in targeting CSC.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Carcinoma de Células Escamosas
/
Espécies Reativas de Oxigênio
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Carcinoma de Células Escamosas de Cabeça e Pescoço
Limite:
Humans
Idioma:
En
Revista:
Semin Cancer Biol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2018
Tipo de documento:
Article