Loss of E-cadherin Enhances IGF1-IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors.

Nagle, Alison M; Levine, Kevin M; Tasdemir, Nilgun; Scott, Julie A; Burlbaugh, Kara; Kehm, Justin; Katz, Tiffany A; Boone, David N; Jacobsen, Britta M; Atkinson, Jennifer M; Oesterreich, Steffi; Lee, Adrian V

Nagle, Alison M; Levine, Kevin M; Tasdemir, Nilgun; Scott, Julie A; Burlbaugh, Kara; Kehm, Justin; Katz, Tiffany A; Boone, David N; Jacobsen, Britta M; Atkinson, Jennifer M; Oesterreich, Steffi; Lee, Adrian V.

Afiliação

Nagle AM; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Levine KM; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee Women's Research Institute, Pittsburgh, Pennsylvania.
Tasdemir N; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee Women's Research Institute, Pittsburgh, Pennsylvania.
Scott JA; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Burlbaugh K; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Kehm J; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee Women's Research Institute, Pittsburgh, Pennsylvania.
Katz TA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Boone DN; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee Women's Research Institute, Pittsburgh, Pennsylvania.
Jacobsen BM; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee Women's Research Institute, Pittsburgh, Pennsylvania.
Atkinson JM; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee Women's Research Institute, Pittsburgh, Pennsylvania.
Oesterreich S; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Lee AV; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee Women's Research Institute, Pittsburgh, Pennsylvania.

Clin Cancer Res ; 24(20): 5165-5177, 2018 10 15.

Article em En | MEDLINE | ID: mdl-29941485

Assuntos

Antineoplásicos/farmacologia; Caderinas/metabolismo; Resistencia a Medicamentos Antineoplásicos; Fator de Crescimento Insulin-Like I/metabolismo; Receptores de Somatomedina/metabolismo; Transdução de Sinais/efeitos dos fármacos; Animais; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Caderinas/genética; Ciclo Celular/genética; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Modelos Animais de Doenças; Relação Dose-Resposta a Droga; Sinergismo Farmacológico; Feminino; Perfilação da Expressão Gênica; Humanos; Imuno-Histoquímica; Fator de Crescimento Insulin-Like I/antagonistas & inibidores; Camundongos; RNA Interferente Pequeno/genética; Receptor IGF Tipo 1; Receptores de Somatomedina/antagonistas & inibidores; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Transdução de Sinais / Caderinas / Receptores de Somatomedina / Resistencia a Medicamentos Antineoplásicos / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article

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