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Proteasome inhibition with bortezomib induces a therapeutically relevant depletion of plasma cells in SLE but does not target their precursors.
Alexander, Tobias; Cheng, Qingyu; Klotsche, Jens; Khodadadi, Laleh; Waka, Aderajew; Biesen, Robert; Hoyer, Bimba F; Burmester, Gerd R; Radbruch, Andreas; Hiepe, Falk.
Afiliação
  • Alexander T; Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Germany.
  • Cheng Q; German Rheumatism Research Center (DRFZ), a Leibniz Institute, Autoimmunology Group, Berlin, Germany.
  • Klotsche J; Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Germany.
  • Khodadadi L; German Rheumatism Research Center (DRFZ), a Leibniz Institute, Autoimmunology Group, Berlin, Germany.
  • Waka A; German Rheumatism Research Center (DRFZ), a Leibniz Institute, Epidemiology Group, Berlin, Germany.
  • Biesen R; Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Germany.
  • Hoyer BF; German Rheumatism Research Center (DRFZ), a Leibniz Institute, Autoimmunology Group, Berlin, Germany.
  • Burmester GR; Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Germany.
  • Radbruch A; German Rheumatism Research Center (DRFZ), a Leibniz Institute, Autoimmunology Group, Berlin, Germany.
  • Hiepe F; Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Germany.
Eur J Immunol ; 48(9): 1573-1579, 2018 09.
Article em En | MEDLINE | ID: mdl-29979809
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmócitos / Autoanticorpos / Complexo de Endopeptidases do Proteassoma / Células Precursoras de Linfócitos B / Células Precursoras de Linfócitos T / Inibidores de Proteassoma / Bortezomib / Lúpus Eritematoso Sistêmico Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Eur J Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmócitos / Autoanticorpos / Complexo de Endopeptidases do Proteassoma / Células Precursoras de Linfócitos B / Células Precursoras de Linfócitos T / Inibidores de Proteassoma / Bortezomib / Lúpus Eritematoso Sistêmico Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Eur J Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha