Prognosis of post-stroke status epilepticus: Effects of time difference between the two events.
Seizure
; 60: 172-177, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-30015150
ABSTRACT
PURPOSE:
This study aimed to investigate the prognosis of patients with status epilepticus (SE) following stroke, focusing on the timing of SE after the event and other unexplored variables.METHODS:
All consecutive patients experiencing post-stroke SE (PSSE) in our center were included (2011-2016). We analyzed SE- and stroke-related factors in relation to the patients' outcome.RESULTS:
95 patients with PSSE (54 ischemic and 41 hemorrhagic stroke) were analyzed; 40 were women (42.1%) and mean age was 72.7⯱â¯13.56 years. 51(53.7%) showed prominent motor symptoms, 49(51.6%) needed >2 antiepileptic drugs, and 27(28.4%) required anesthetics. Median duration of SE was 12â¯h (1-240). Median time from stroke to SE was 15 days (0-532). At discharge, logistic regression identified SE within 72â¯h after stroke (pâ¯=â¯0.004), baseline mSTESS (pâ¯=â¯0.009), and lesion volume (pâ¯=â¯0.001) as independent factors predicting mortality. Female sex (pâ¯=â¯0.019), SE duration >12â¯h (pâ¯=â¯0.005), temporal lobe involvement (pâ¯=â¯0.029), and stroke-to-SE time <90 days (pâ¯<â¯0.0001) were independent predictors of functional decline. At long-term follow-up, SE occurring within 72â¯h after stroke (pâ¯=â¯0.0001), SE duration (pâ¯=â¯0.004), and baseline mSTESS score (pâ¯=â¯0.012) remained as predictive of mortality.CONCLUSIONS:
The timing of SE after stroke is associated with different consequences mortality was higher when SE occurred within the first 72â¯h after stroke and this risk persisted at follow-up, whereas risk of functional decline was higher when SE occurred during the first 3 months. Other factors such as the mSTESS score and SE duration were associated with outcome at both discharge and long-term follow-up.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estado Epiléptico
/
Acidente Vascular Cerebral
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
/
Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Seizure
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2018
Tipo de documento:
Article