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Potassium Iodide-Promoted One-Pot Synthesis of Fluoroalkylated Quinoxalines via a Tandem Michael Addition/Azidation/Cycloamination Approach.
Wu, Jun; Zhang, Hui; Ding, Xiao; Tan, Xuefei; Chen, Jie; He, Weimin; Deng, Hongmei; Song, Liping; Shen, Hong C; Cao, Weiguo.
Afiliação
  • Wu J; School of Materials Science and Engineering , Shanghai University , Shanghai 200444 , China.
  • Zhang H; Roche Innovation Center Shanghai , Roche R&D Center (China) Ltd. , Shanghai 201203 , China.
  • Ding X; Department of Chemistry , Shanghai University , Shanghai 200444 , China.
  • Tan X; Roche Innovation Center Shanghai , Roche R&D Center (China) Ltd. , Shanghai 201203 , China.
  • Chen J; Roche Innovation Center Shanghai , Roche R&D Center (China) Ltd. , Shanghai 201203 , China.
  • He W; Department of Chemistry , Shanghai University , Shanghai 200444 , China.
  • Deng H; Department of Chemistry , Shanghai University , Shanghai 200444 , China.
  • Song L; Department of Chemistry , Shanghai University , Shanghai 200444 , China.
  • Shen HC; School of Materials Science and Engineering , Shanghai University , Shanghai 200444 , China.
  • Cao W; Department of Chemistry , Shanghai University , Shanghai 200444 , China.
J Org Chem ; 83(16): 9422-9429, 2018 08 17.
Article em En | MEDLINE | ID: mdl-30025451
ABSTRACT
Fluoroalkylated quinoxlines with various groups were efficiently synthesized via a one-pot tandem Michael addition/azidation/cycloamination process. Under the mild and metal-free conditions, a bis-imine intermediate (4a) was detected and isolated for the first time. KI played a crucial role in this reaction. The mechanism was described.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China