Diagnostic accuracy of NUDT15 gene variants for thiopurine-induced leukopenia: a systematic review and meta-analysis.

Cargnin, Sarah; Genazzani, Armando A; Canonico, Pier Luigi; Terrazzino, Salvatore

Cargnin, Sarah; Genazzani, Armando A; Canonico, Pier Luigi; Terrazzino, Salvatore.

Afiliação

Cargnin S; Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, Novara, Italy.
Genazzani AA; Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, Novara, Italy.
Canonico PL; Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, Novara, Italy.
Terrazzino S; Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, Novara, Italy. Electronic address: salvatore.terrazzino@uniupo.it.

Pharmacol Res ; 135: 102-111, 2018 09.

Article em En | MEDLINE | ID: mdl-30048756

Assuntos

Antineoplásicos/efeitos adversos; Azatioprina/efeitos adversos; Leucopenia/induzido quimicamente; Leucopenia/genética; Mercaptopurina/efeitos adversos; Pirofosfatases/genética; Tioguanina/efeitos adversos; Humanos; Leucopenia/diagnóstico; Polimorfismo Genético

Palavras-chave

Leukopenia; NUDT15; Polymorphisms; Thiopurines; Toxicity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirofosfatases / Azatioprina / Tioguanina / Leucopenia / Mercaptopurina / Antineoplásicos Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália

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