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A Retrospective: 10 Years of Oligo(phenylene-ethynylene) Electrolytes: Demystifying Nanomaterials.
Whitten, David G; Tang, Yanli; Zhou, Zhijun; Yang, Jianzhong; Wang, Ying; Hill, Eric H; Pappas, Harry C; Donabedian, Patrick L; Chi, Eva Y.
Afiliação
  • Whitten DG; Department of Chemical and Biological Engineering , University of New Mexico , Albuquerque , New Mexico 87131 , United States.
  • Tang Y; Department of Chemical and Biological Engineering , University of New Mexico , Albuquerque , New Mexico 87131 , United States.
  • Zhou Z; Department of Chemical and Biological Engineering , University of New Mexico , Albuquerque , New Mexico 87131 , United States.
  • Yang J; Department of Chemical and Biological Engineering , University of New Mexico , Albuquerque , New Mexico 87131 , United States.
  • Wang Y; Department of Chemical and Biological Engineering , University of New Mexico , Albuquerque , New Mexico 87131 , United States.
  • Hill EH; Department of Chemical and Biological Engineering , University of New Mexico , Albuquerque , New Mexico 87131 , United States.
  • Pappas HC; Department of Chemical and Biological Engineering , University of New Mexico , Albuquerque , New Mexico 87131 , United States.
  • Donabedian PL; Department of Chemical and Biological Engineering , University of New Mexico , Albuquerque , New Mexico 87131 , United States.
  • Chi EY; Department of Chemical and Biological Engineering , University of New Mexico , Albuquerque , New Mexico 87131 , United States.
Langmuir ; 35(2): 307-325, 2019 01 15.
Article em En | MEDLINE | ID: mdl-30056722
ABSTRACT
In this retrospective, we first reviewed the synthesis of the oligo(phenylene-ethynylene) electrolytes (OPEs) we created in the past 10 years. Since the general antimicrobial activity of these OPEs had been reported in our previous account in Langmuir, we are focusing only on the unusual spectroscopic and photophysical properties of these OPEs and their complexes with anionic scaffolds and detergents in this Feature Article. We applied classical all-atom MD simulations to study the hydrogen bonding environment in the water surrounding the OPEs with and without detergents present. Our finding is that OPEs could form a unit cluster or unit aggregate with a few oppositely charged detergent molecules, indicating that the photostability and photoreactivity of these OPEs might be considerably altered with important consequences to their activity as antimicrobials and fluorescence-based sensors. Thus, in the following sections, we showed that OPE complexes with detergents exhibit enhanced light-activated biocidal activity compared to either OPE or detergent individually. We also found that similar complexes between certain OPEs and biolipids could be used to construct sensors for the enzyme activity. Finally, the OPEs could covalently bind to microsphere surfaces to make a bactericidal surface, which is simpler and more ordered than the surface grafted from microspheres with polyelectrolytes. In the Conclusions and Prospects section, we briefly summarize the properties of OPEs developed so far and future areas for investigation.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Langmuir Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Langmuir Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos