Structural and functional effects of myosin-binding protein-C phosphorylation in heart muscle are not mimicked by serine-to-aspartate substitutions.

Kampourakis, Thomas; Ponnam, Saraswathi; Sun, Yin-Biao; Sevrieva, Ivanka; Irving, Malcolm

Kampourakis, Thomas; Ponnam, Saraswathi; Sun, Yin-Biao; Sevrieva, Ivanka; Irving, Malcolm.

Afiliação

Kampourakis T; From the Randall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, School of Basic and Medical Biosciences, King's College London, London SE1 1UL, United Kingdom thomas.kampourakis@kcl.ac.uk.
Ponnam S; From the Randall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, School of Basic and Medical Biosciences, King's College London, London SE1 1UL, United Kingdom.
Sun YB; From the Randall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, School of Basic and Medical Biosciences, King's College London, London SE1 1UL, United Kingdom.
Sevrieva I; From the Randall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, School of Basic and Medical Biosciences, King's College London, London SE1 1UL, United Kingdom.
Irving M; From the Randall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, School of Basic and Medical Biosciences, King's College London, London SE1 1UL, United Kingdom.

J Biol Chem ; 293(37): 14270-14275, 2018 09 14.

Article em En | MEDLINE | ID: mdl-30082313

Assuntos

Substituição de Aminoácidos; Proteínas de Transporte/química; Proteínas de Transporte/metabolismo; Músculos/metabolismo; Miocárdio/metabolismo; Sequência de Aminoácidos; Animais; Ácido Aspártico/genética; Ácido Aspártico/metabolismo; Cálcio/metabolismo; Proteínas de Transporte/genética; Cinética; Masculino; Miosinas/química; Miosinas/metabolismo; Fosforilação; Ligação Proteica; Ratos; Ratos Wistar; Serina/genética; Serina/metabolismo

Palavras-chave

cardiac muscle; cardiac muscle regulation; muscle; myofibril; myosin; myosin-binding protein-C; phosphomimetic; phosphorylation; polarized fluorescence muscle fiber; protein phosphorylation; tris-phosphorylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Transporte / Substituição de Aminoácidos / Músculos / Miocárdio Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido

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