A natural flavonoid lawsonaringenin induces cell cycle arrest and apoptosis in HT-29 colorectal cancer cells by targeting multiple signalling pathways.

Anwar, Areeba; Uddin, Nizam; Siddiqui, Bina Shaheen; Siddiqui, Rafat Ali; Begum, Sabira; Choudhary, Muhammad Iqbal

Anwar, Areeba; Uddin, Nizam; Siddiqui, Bina Shaheen; Siddiqui, Rafat Ali; Begum, Sabira; Choudhary, Muhammad Iqbal.

Afiliação

Anwar A; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. areeba_anwar@ymail.com.
Uddin N; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Siddiqui BS; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Siddiqui RA; Nutrition Science and Food Chemistry Laboratory, Agriculture Research Station, Virginia State University, Petersburg, VA, 23806, USA.
Begum S; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Choudhary MI; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. iqbal.choudhary@iccs.edu.

Mol Biol Rep ; 45(5): 1339-1348, 2018 Oct.

Article em En | MEDLINE | ID: mdl-30088202

Assuntos

Neoplasias Colorretais/tratamento farmacológico; Flavonoides/farmacologia; Lawsonia (Planta)/química; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Ciclo Celular/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Fluoruracila/farmacologia; Células HT29; Humanos; Fitoterapia/métodos; Extratos Vegetais/farmacologia; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Apoptosis; Colorectal cancer; Flavonoid; HT-29 cells; Lawsonia alba Lam.; ß-Catenin signalling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Neoplasias Colorretais / Lawsonia (Planta) Limite: Humans Idioma: En Revista: Mol Biol Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Paquistão

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