GTPases Rac1 and Ras Signaling from Endosomes.
Prog Mol Subcell Biol
; 57: 65-105, 2018.
Article
em En
| MEDLINE
| ID: mdl-30097772
ABSTRACT
The endocytic compartment is not only the functional continuity of the plasma membrane but consists of a diverse collection of intracellular heterogeneous complex structures that transport, amplify, sustain, and/or sort signaling molecules. Over the years, it has become evident that early, late, and recycling endosomes represent an interconnected vesicular-tubular network able to form signaling platforms that dynamically and efficiently translate extracellular signals into biological outcome. Cell activation, differentiation, migration, death, and survival are some of the endpoints of endosomal signaling. Hence, to understand the role of the endosomal system in signal transduction in space and time, it is therefore necessary to dissect and identify the plethora of decoders that are operational in the different steps along the endocytic pathway. In this chapter, we focus on the regulation of spatiotemporal signaling in cells, considering endosomes as central platforms, in which several small GTPases proteins of the Ras superfamily, in particular Ras and Rac1, actively participate to control cellular processes like proliferation and cell mobility.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endossomos
/
Proteínas ras
/
Proteínas rac1 de Ligação ao GTP
/
Proliferação de Células
Limite:
Humans
Idioma:
En
Revista:
Prog Mol Subcell Biol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha