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Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.
Koohy, Hashem; Bolland, Daniel J; Matheson, Louise S; Schoenfelder, Stefan; Stellato, Claudia; Dimond, Andrew; Várnai, Csilla; Chovanec, Peter; Chessa, Tamara; Denizot, Jeremy; Manzano Garcia, Raquel; Wingett, Steven W; Freire-Pritchett, Paula; Nagano, Takashi; Hawkins, Phillip; Stephens, Len; Elderkin, Sarah; Spivakov, Mikhail; Fraser, Peter; Corcoran, Anne E; Varga-Weisz, Patrick D.
Afiliação
  • Koohy H; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Bolland DJ; Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Matheson LS; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Schoenfelder S; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK.
  • Stellato C; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Dimond A; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK.
  • Várnai C; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Chovanec P; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Chessa T; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Denizot J; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Manzano Garcia R; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Wingett SW; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK.
  • Freire-Pritchett P; Signalling, Babraham Institute, Cambridge, UK.
  • Nagano T; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Hawkins P; Present address: Université Clermont Auvergne, Inserm U1071, M2iSH, USC-INRA 2018, F-, 63000, Clermont-Ferrand, France.
  • Stephens L; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Elderkin S; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Spivakov M; Bioinformatics, Babraham Institute, Cambridge, UK.
  • Fraser P; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
  • Corcoran AE; Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
  • Varga-Weisz PD; Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.
Genome Biol ; 19(1): 126, 2018 09 05.
Article em En | MEDLINE | ID: mdl-30180872
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Somatomedinas / Linfócitos B / Cromatina / Epigênese Genética / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Genome Biol Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Somatomedinas / Linfócitos B / Cromatina / Epigênese Genética / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Genome Biol Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido