ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links.

Mutreja, Karun; Krietsch, Jana; Hess, Jeannine; Ursich, Sebastian; Berti, Matteo; Roessler, Fabienne K; Zellweger, Ralph; Patra, Malay; Gasser, Gilles; Lopes, Massimo

Mutreja, Karun; Krietsch, Jana; Hess, Jeannine; Ursich, Sebastian; Berti, Matteo; Roessler, Fabienne K; Zellweger, Ralph; Patra, Malay; Gasser, Gilles; Lopes, Massimo.

Afiliação

Mutreja K; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Krietsch J; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Hess J; Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Ursich S; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Berti M; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Roessler FK; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland; Center for Microscopy and Image Analysis, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Zellweger R; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Patra M; Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Gasser G; Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Lopes M; Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. Electronic address: lopes@imcr.uzh.ch.

Cell Rep ; 24(10): 2629-2642.e5, 2018 09 04.

Article em En | MEDLINE | ID: mdl-30184498

Assuntos

Quebra Cromossômica; Dano ao DNA/genética; Replicação do DNA/genética; DNA/metabolismo; Western Blotting; Linhagem Celular Tumoral; Ensaio Cometa; DNA/genética; DNA/ultraestrutura; Dano ao DNA/fisiologia; Replicação do DNA/fisiologia; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Citometria de Fluxo; Imunofluorescência; Humanos; Microscopia Eletrônica; Rad51 Recombinase/genética; Rad51 Recombinase/metabolismo

Palavras-chave

ATR checkpoint; DNA interstrand crosslinks; DNA replication; DNA replication stress response; ICL immunolabeling; electron microscopy; fork traverse; global fork slowing; replication fork reversal

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / DNA / Quebra Cromossômica / Replicação do DNA Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Suíça

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