Recent advances in ß-lactam synthesis.
Org Biomol Chem
; 16(38): 6840-6852, 2018 10 03.
Article
em En
| MEDLINE
| ID: mdl-30209477
ABSTRACT
During the past century, ß-lactams have been identified as the core of penicillin and since then several strategies have been developed for their synthesis. Traditional methods for ß-lactam synthesis usually involved amide bond formation and the Staudinger reaction. In recent years, by the advancement of photo- and transition metal-catalysis, several new methods have been reported for ß-lactam synthesis. For instance ligand assisted metal catalyzed C-H activation/intermolecular oxidative amidation draws attention for ß-lactam synthesis. In this review we introduce methods for ß-lactam synthesis and present newly developed reactions. We approach the synthesis of ß-lactams according to different retro synthesis strategies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Beta-Lactamas
/
Técnicas de Química Sintética
/
Antibacterianos
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos