Novel TGF-ß1 inhibitor antagonizes TGF-ß1-induced epithelial-mesenchymal transition in human A549 lung cancer cells.

Jeong, Ji-Hoon; Jang, Hae Jin; Kwak, Sungmin; Sung, Gi-Jun; Park, Seung-Ho; Song, Ji-Hye; Kim, Hyunhee; Na, Younghwa; Choi, Kyung-Chul

Jeong, Ji-Hoon; Jang, Hae Jin; Kwak, Sungmin; Sung, Gi-Jun; Park, Seung-Ho; Song, Ji-Hye; Kim, Hyunhee; Na, Younghwa; Choi, Kyung-Chul.

Afiliação

Jeong JH; Department of Biomedical Sciences, Asan Medical Center, AMIST, University of Ulsan College of Medicine, Seoul, South Korea.
Jang HJ; Department of Pharmacology, University of Ulsan College of Medicine, Seoul, South Korea.
Kwak S; College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, South Korea.
Sung GJ; Department of Biomedical Sciences, Asan Medical Center, AMIST, University of Ulsan College of Medicine, Seoul, South Korea.
Park SH; Department of Pharmacology, University of Ulsan College of Medicine, Seoul, South Korea.
Song JH; Department of Biomedical Sciences, Asan Medical Center, AMIST, University of Ulsan College of Medicine, Seoul, South Korea.
Kim H; Department of Pharmacology, University of Ulsan College of Medicine, Seoul, South Korea.
Na Y; Department of Biomedical Sciences, Asan Medical Center, AMIST, University of Ulsan College of Medicine, Seoul, South Korea.
Choi KC; Department of Pharmacology, University of Ulsan College of Medicine, Seoul, South Korea.

J Cell Biochem ; 120(1): 977-987, 2019 01.

Article em En | MEDLINE | ID: mdl-30216515

Assuntos

Chalconas/farmacologia; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patologia; Fator de Crescimento Transformador beta1/antagonistas & inibidores; Fator de Crescimento Transformador beta1/metabolismo; Células A549; Caderinas/genética; Caderinas/metabolismo; Movimento Celular/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Humanos; Metaloproteinase 2 da Matriz/genética; Metaloproteinase 2 da Matriz/metabolismo; Metaloproteinase 9 da Matriz/genética; Metaloproteinase 9 da Matriz/metabolismo; Invasividade Neoplásica; Fosforilação/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Proteína Smad2/genética; Proteína Smad2/metabolismo

Palavras-chave

chalcone; epithelial-mesenchymal transition (EMT); invasion; lung cancer; migration; transforming growth factor-ß1 (TGF-ß1)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chalconas / Fator de Crescimento Transformador beta1 / Transição Epitelial-Mesenquimal / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: J Cell Biochem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Coréia do Sul

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