Fetal sex modifies the effect of maternal macronutrient intake on the incidence of small-for-gestational-age births: a prospective observational cohort study.
Am J Clin Nutr
; 108(4): 814-820, 2018 10 01.
Article
em En
| MEDLINE
| ID: mdl-30239558
ABSTRACT
Background:
Maternal macronutrient intake is likely to play a pivotal role in fetoplacental growth. Male fetuses grow faster and their growth is more responsive to maternal size.Objective:
We assessed the role of fetal sex in modifying the effect of maternal macronutrient intake on the risk of small-for-gestational-age (SGA) birth.Design:
This was a prospective, observational cohort study of 2035 births from an urban South Asian Indian population. Maternal intakes of total energy and macronutrients were recorded by validated food-frequency questionnaires. The interaction of trimester 1 macronutrient intake with fetal sex was tested on the outcome of SGA births.Results:
The prevalence of SGA was 28%. Trimester 1 macronutrient composition was high in carbohydrate and low in fat (means ± SDs-carbohydrate 64.6% ± 5.1%; protein 11.5% ± 1.1%; and fat 23.9% ± 4.4% of energy). Higher carbohydrate and lower fat consumption were each associated with an increased risk of SGA [adjusted OR (AOR) per 5% of energy (95% CI) carbohydrate 1.15 (1.01, 1.32); fat 0.83 (0.71, 0.97)] specifically among male births (males n = 1047; females n = 988). Dietary intake of >70% of energy from carbohydrate was also associated with increased risk (AOR 1.67; 95% CI 1.00, 2.78), whereas >25% of energy from fat intake was associated with decreased risk (AOR 0.61; 95% CI 0.41, 0.90) of SGA in male births.Conclusions:
Higher carbohydrate and lower fat intakes early in pregnancy were associated with increased risk of male SGA births. Therefore, we speculate that fetal sex acts as a modifier of the role of maternal periconceptional nutrition in optimal fetoplacental growth.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Pequeno para a Idade Gestacional
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Carboidratos da Dieta
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Gorduras na Dieta
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Fenômenos Fisiológicos da Nutrição Pré-Natal
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Desenvolvimento Fetal
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Dieta
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Comportamento Alimentar
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Revista:
Am J Clin Nutr
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Índia