Reaching toward underexplored targets in antibacterial drug design.
Drug Dev Res
; 80(1): 6-10, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30312991
ABSTRACT
The increase of antimicrobial resistance necessitates the renewal and strong research involvement in antibacterial drug design. In the following work, we comment on the key approaches used in development of new antibacterials, focusing on intracellular therapeutic targets that have been so far mostly underexplored the enzymes of the Mur pathway MurA to MurF. We identify common obstacles observed during research on MurA, MurB, and Mur ligases inhibitors and their development into potential antibacterial compounds, and discern several approaches and solutions to tackle the whole-cell activity of designed compounds. Furthermore, we consolidate recent literature reports and encourage the further research on Mur enzymes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
/
Sistemas de Liberação de Medicamentos
/
Antibacterianos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Dev Res
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Eslovênia