Stereoselective pharmacokinetics of (R)-(+)- and (S)-(-)-rabeprazole in human using chiral LC-MS/MS after administration of rabeprazole sodium enteric-coated tablet.

Sun, Lu-Ning; Shen, Yi-Wen; Ying, Yu-Wen; Li, Duo; Li, Teng-Fei; Zhang, Xue-Hui; Zhao, Ping; Ding, Li; Wang, Yong-Qing

Sun, Lu-Ning; Shen, Yi-Wen; Ying, Yu-Wen; Li, Duo; Li, Teng-Fei; Zhang, Xue-Hui; Zhao, Ping; Ding, Li; Wang, Yong-Qing.

Afiliação

Sun LN; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Shen YW; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ying YW; Research Division of Clinical Pharmacology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Li D; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Li TF; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Zhang XH; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Zhao P; Department of Pharmacy, Jiangsu Shengze Hospital, Suzhou, China.
Ding L; Department of Pharmacy, Jiangsu Shengze Hospital, Suzhou, China.
Wang YQ; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.

Chirality ; 30(12): 1277-1286, 2018 12.

Article em En | MEDLINE | ID: mdl-30321480

Assuntos

Cromatografia Líquida/métodos; Rabeprazol/química; Rabeprazol/farmacocinética; Espectrometria de Massas em Tandem/métodos; Administração Oral; Adolescente; Adulto; Calibragem; Estabilidade de Medicamentos; Humanos; Limite de Detecção; Rabeprazol/administração & dosagem; Rabeprazol/sangue; Reprodutibilidade dos Testes; Sensibilidade e Especificidade; Estereoisomerismo; Comprimidos com Revestimento Entérico

Palavras-chave

(R)-(+)-rabeprazole; (S)-(−)-rabeprazole; chiral separation; liquid chromatography-tandem mass spectrometry; pharmacokinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Espectrometria de Massas em Tandem / Rabeprazol Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Humans Idioma: En Revista: Chirality Assunto da revista: BIOLOGIA MOLECULAR / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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