Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits.

Hannon, Eilis; Gorrie-Stone, Tyler J; Smart, Melissa C; Burrage, Joe; Hughes, Amanda; Bao, Yanchun; Kumari, Meena; Schalkwyk, Leonard C; Mill, Jonathan

Hannon, Eilis; Gorrie-Stone, Tyler J; Smart, Melissa C; Burrage, Joe; Hughes, Amanda; Bao, Yanchun; Kumari, Meena; Schalkwyk, Leonard C; Mill, Jonathan.

Afiliação

Hannon E; University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, United Kingdom.
Gorrie-Stone TJ; School of Biological Sciences, University of Essex, Colchester, CO4 3SQ, United Kingdom.
Smart MC; Institute for Social and Economic Research, University of Essex, Colchester CO3 3LG, United Kingdom.
Burrage J; University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, United Kingdom.
Hughes A; Institute for Social and Economic Research, University of Essex, Colchester CO3 3LG, United Kingdom.
Bao Y; Institute for Social and Economic Research, University of Essex, Colchester CO3 3LG, United Kingdom.
Kumari M; Institute for Social and Economic Research, University of Essex, Colchester CO3 3LG, United Kingdom.
Schalkwyk LC; School of Biological Sciences, University of Essex, Colchester, CO4 3SQ, United Kingdom.
Mill J; University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, United Kingdom. Electronic address: j.mill@exeter.ac.uk.

Am J Hum Genet ; 103(5): 654-665, 2018 11 01.

Article em En | MEDLINE | ID: mdl-30401456

Assuntos

Metilação de DNA/genética; DNA/genética; Epigênese Genética/genética; Expressão Gênica/genética; Variação Genética/genética; Locos de Características Quantitativas/genética; Transcriptoma/genética; Estudo de Associação Genômica Ampla/métodos; Humanos; Estudos Longitudinais; Fenótipo; Característica Quantitativa Herdável; Transcrição Gênica/genética

Palavras-chave

DNA methylation; GWAS; QTL; SMR; SNP; complex traits; gene expression; genome-wide association study; pleiotropy; quantitative-trait loci; single-nucleotide polymorphism; summary-data-based Mendelian randomization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / DNA / Expressão Gênica / Metilação de DNA / Locos de Características Quantitativas / Epigênese Genética / Transcriptoma Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Am J Hum Genet Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido

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