Caffeine improves bladder function in streptozotocin-induced diabetic rats.
Neurourol Urodyn
; 38(1): 81-86, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30411811
ABSTRACT
AIMS:
To examine the protective effects of caffeine in rats with diabetes mellitus (DM) by using urodynamics.METHODS:
Female Sprague-Dawley rats (n = 24) were divided into four groups control group, DM group, DM + caffeine (5 mg/kg/day), and DM + caffeine (10 mg/kg/day). DM was induced by streptozotocin (STZ). Cystometric studies were conducted on all rats. After 8 weeks of treatment with caffeine, the urodynamic parameters, including bladder capacity, residual urine volume, voiding time, and peak voiding pressure, were measured.RESULTS:
DM rats had a higher bladder capacity and post-void residual urine volume (PVR), an increased voiding time and peak voiding pressure, and a markedly lower voiding efficiency than the control group rats. After treatment with caffeine, bladder capacity, post-void residual urine volume, and peak voiding pressure were significant lower than those in the DM group, but voiding efficiency was markedly higher.CONCLUSION:
The results suggested that caffeine (5 or 10 mg/kg/day) may improve the bladder function at 8 weeks after STZ induction. Thus, this may represent a potential strategy to increase voiding efficiency in diabetes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bexiga Urinária
/
Cafeína
/
Diabetes Mellitus Experimental
/
Estimulantes do Sistema Nervoso Central
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Neurourol Urodyn
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China