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Elevated Membrane Cholesterol Disrupts Lysosomal Degradation to Induce ß-Amyloid Accumulation: The Potential Mechanism Underlying Augmentation of ß-Amyloid Pathology by Type 2 Diabetes Mellitus.
Takeuchi, Shingo; Ueda, Naoya; Suzuki, Keiko; Shimozawa, Nobuhiro; Yasutomi, Yasuhiro; Kimura, Nobuyuki.
Afiliação
  • Takeuchi S; Section of Cell Biology and Pathology, Department of Alzheimer's Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan.
  • Ueda N; Section of Cell Biology and Pathology, Department of Alzheimer's Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan.
  • Suzuki K; Section of Cell Biology and Pathology, Department of Alzheimer's Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan.
  • Shimozawa N; Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan.
  • Yasutomi Y; Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan.
  • Kimura N; Section of Cell Biology and Pathology, Department of Alzheimer's Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan. Electronic address: kimura@ncgg.go.jp.
Am J Pathol ; 189(2): 391-404, 2019 02.
Article em En | MEDLINE | ID: mdl-30448407
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Colesterol / Peptídeos beta-Amiloides / Complicações do Diabetes / Diabetes Mellitus Tipo 2 / Doença de Alzheimer / Lisossomos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Am J Pathol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Colesterol / Peptídeos beta-Amiloides / Complicações do Diabetes / Diabetes Mellitus Tipo 2 / Doença de Alzheimer / Lisossomos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Am J Pathol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão