Synthesis of Difluoroalkyl Unsaturated ß-Amino Acid Derivatives Exclusively through Alkyne Difunctionalization.
J Org Chem
; 83(23): 14626-14636, 2018 12 07.
Article
em En
| MEDLINE
| ID: mdl-30451495
ABSTRACT
Alkynes difunctionalization is a powerful strategy in organic synthesis that provides a convenient synthetic entry for internal alkenes. The main challenge in this field was considered to be the geometry control of the newly formed double bond (thermodynamically controlled or kinetically controlled). Herein, we report a novel procedure (through the cyclic compounds broken) to completely control the regioselectivity of olefins. The products, difluoroalkyl unsaturated ß-amino acid derivatives, have potential applications in some important pharmaceuticals on account of the special nature of fluorine atoms.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China