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Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Kyriakou, Eleni; Schmidt, Stefanie; Dodd, Garron T; Pfuhlmann, Katrin; Simonds, Stephanie E; Lenhart, Dominik; Geerlof, Arie; Schriever, Sonja C; De Angelis, Meri; Schramm, Karl-Werner; Plettenburg, Oliver; Cowley, Michael A; Tiganis, Tony; Tschöp, Matthias H; Pfluger, Paul T; Sattler, Michael; Messias, Ana C.
Afiliação
  • Kyriakou E; Institute of Structural Biology , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
  • Schmidt S; Biomolecular NMR and Center for Integrated Protein Science Munich at Department of Chemistry , Technical University of Munich , 85747 Garching , Germany.
  • Dodd GT; Institute of Structural Biology , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
  • Pfuhlmann K; Biomolecular NMR and Center for Integrated Protein Science Munich at Department of Chemistry , Technical University of Munich , 85747 Garching , Germany.
  • Simonds SE; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology , Monash University , Victoria 3800 , Australia.
  • Lenhart D; Research Unit Neurobiology of Diabetes , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
  • Geerlof A; Institute for Diabetes and Obesity , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
  • Schriever SC; Division of Metabolic Diseases , Technische Universität München , 80333 Munich , Germany.
  • De Angelis M; German Center for Diabetes Research (DZD) , 85764 Neuherberg , Germany.
  • Schramm KW; Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, and Department of Physiology , Monash University , Victoria 3800 , Australia.
  • Plettenburg O; Institute of Structural Biology , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
  • Cowley MA; Biomolecular NMR and Center for Integrated Protein Science Munich at Department of Chemistry , Technical University of Munich , 85747 Garching , Germany.
  • Tiganis T; Institute of Medicinal Chemistry , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
  • Tschöp MH; Institute of Structural Biology , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
  • Pfluger PT; Research Unit Neurobiology of Diabetes , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
  • Sattler M; Institute for Diabetes and Obesity , Helmholtz Zentrum München , 85764 Neuherberg , Germany.
  • Messias AC; German Center for Diabetes Research (DZD) , 85764 Neuherberg , Germany.
J Med Chem ; 61(24): 11144-11157, 2018 12 27.
Article em En | MEDLINE | ID: mdl-30525586
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Fármacos Antiobesidade / Proteína Tirosina Fosfatase não Receptora Tipo 1 / Proteína Tirosina Fosfatase não Receptora Tipo 2 / Obesidade Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Fármacos Antiobesidade / Proteína Tirosina Fosfatase não Receptora Tipo 1 / Proteína Tirosina Fosfatase não Receptora Tipo 2 / Obesidade Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha