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Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school-aged children with obesity/overweight and with normal weight.
González-Herrera, Lizbeth; Zavala-Castro, Jorge; Ayala-Cáceres, Claudia; Pérez-Mendoza, Gerardo; López-González, María José; Pinto-Escalante, Doris; Canto-Cetina, Thelma; García-Escalante, María Guadalupe; Rubi-Castellanos, Rodrigo; Contreras-Capetillo, Silvina; Herrera-Sanchez, Fernando; Méndez-Domínguez, Nina; Alcocer-Gamboa, Alberto.
Afiliação
  • González-Herrera L; Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, Yucatán, Mexico.
  • Zavala-Castro J; Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, Yucatán, Mexico.
  • Ayala-Cáceres C; Escuela de Nutrición, Universidad Vizcaya de las Américas Plantel Mérida, Yucatán, México.
  • Pérez-Mendoza G; Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, Yucatán, Mexico.
  • López-González MJ; DIMYGEN Laboratorio S.C. P, Mérida, Yucatán, Mexico.
  • Pinto-Escalante D; Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, Yucatán, Mexico.
  • Canto-Cetina T; Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, Yucatán, Mexico.
  • García-Escalante MG; Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, Yucatán, Mexico.
  • Rubi-Castellanos R; Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, Yucatán, Mexico.
  • Contreras-Capetillo S; Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, Yucatán, Mexico.
  • Herrera-Sanchez F; Centro de Investigaciones Regionales, Universidad Autónoma de Yucatán, Yucatán, Mexico.
  • Méndez-Domínguez N; Departamento de Ciencias de la Salud, Universidad Marista, Mérida, Yucatán, México.
  • Alcocer-Gamboa A; Programa Integral de Atención a la Obesidad, Secretaria de Educación del Gobierno del Estado de Yucatán, Mérida, Yucatán, Mexico.
Am J Hum Biol ; 31(1): e23192, 2019 01.
Article em En | MEDLINE | ID: mdl-30537186
ABSTRACT

OBJECTIVES:

Genetic variation of the fat mass and obesity associated gene (FTO) has been identified as a risk factor for obesity and obesity traits. Distribution of FTO single nutleotide polymorphisms (SNPs) rs1421085T>C, rs9939609T>A, rs8057044G>A and copy number variation (CNV) was evaluated in association with childhood obesity or overweight status in children with Mayan ethnicity.

METHODS:

We included 318 school-aged children with obesity or overweight status (body mass index [BMI] >85th percentile) and 303 children with normal weight (BMI 15th-85th percentile). Genotyping was performed using real-time polymerase chain reaction (RT-PCR) with TaqMan probes. The cross-sectional study was carried out using univariate and multivariate logistic regression models adjusted for gender.

RESULTS:

FTO-SNP rs1421085 showed significant differences between children with obesity and children with normal weight for the heterozygous genotype (P = 0.003) and for allele frequencies (P = 0.023). Adjusting by gender, significant differences were found in frequencies of the hetezygous genotype of SNPs rs9939609 (P = 0.023) and rs1421085 (P = 0.003) as well as in allele frequencies (P = 0.042 and P = 0.013, respectively) between girls with obesity and girls without obesity. In contrast, SNP rs8057044 was significantly different only between heterozygous overweight versus normal weight boys (P = 0.035) and for the allele frequency of rs8057044 (P = 0.021). The mean relative CNV was significantly higher in male overweight children than in boys with normal weight (P = 0.000).

CONCLUSIONS:

The FTO SNP rs1421085 is a genetic factor associated with obesity in Mayan school-aged children. FTO SNPs rs1421085 and rs9939609 affect genetic susceptibility for obesity only in girls, whereas, SNP rs8057044 and CNV are associated with overweight status only in boys.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Peso Corporal / Sobrepeso / Dioxigenase FTO Dependente de alfa-Cetoglutarato Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Am J Hum Biol Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Peso Corporal / Sobrepeso / Dioxigenase FTO Dependente de alfa-Cetoglutarato Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Am J Hum Biol Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: México