Ligand binding domain interface: A tipping point for pharmacological agents binding with GluN1/2A subunit containing NMDA receptors.

Bledsoe, Douglas; Vacca, Bryanna; Laube, Bodo; Klein, Bradley G; Costa, Blaise

Bledsoe, Douglas; Vacca, Bryanna; Laube, Bodo; Klein, Bradley G; Costa, Blaise.

Afiliação

Bledsoe D; Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA, USA.
Vacca B; Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA, USA.
Laube B; Department of Neurophysiology and Neurosensory Systems, Technical University, Darmstadt, Germany.
Klein BG; Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; School of Neuroscience, Virginia Tech, Blacksburg, VA, USA.
Costa B; Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA, USA; Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; School of Neuroscience, Virginia Tech, Blacksburg, VA, USA. Electronic address: bcosta@vcom.vt.edu.

Eur J Pharmacol ; 844: 216-224, 2019 Feb 05.

Article em En | MEDLINE | ID: mdl-30553788

Assuntos

Subunidades Proteicas/fisiologia; Receptores de N-Metil-D-Aspartato/fisiologia; Ligantes; Preparações Farmacêuticas/metabolismo; Domínios Proteicos

Palavras-chave

Competitive antagonists; Interface; Ligand binding domain (LBD); Memantine; NMDA receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de N-Metil-D-Aspartato / Subunidades Proteicas Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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