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Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial.
Porco, Travis C; Hart, John; Arzika, Ahmed M; Weaver, Jerusha; Kalua, Khumbo; Mrango, Zakayo; Cotter, Sun Y; Stoller, Nicole E; O'Brien, Kieran S; Fry, Dionna M; Vanderschelden, Benjamin; Oldenburg, Catherine E; West, Sheila K; Bailey, Robin L; Keenan, Jeremy D; Lietman, Thomas M.
Afiliação
  • Porco TC; Francis I. Proctor Foundation, University of California, San Francisco.
  • Hart J; Department of Ophthalmology, University of California, San Francisco.
  • Arzika AM; Department of Epidemiology and Biostatistics, University of California, San Francisco.
  • Weaver J; Institute for Global Health Sciences, University of California, San Francisco.
  • Kalua K; London School of Hygiene and Tropical Medicine, United Kingdom.
  • Mrango Z; The Carter Center, Niamey, Niger.
  • Cotter SY; The Dana Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Stoller NE; Blantyre Institute for Community Outreach, Blantyre.
  • O'Brien KS; College of Medicine, University of Malawi, Blantyre.
  • Fry DM; National Institute for Medical Research, Dar es Salaam, Tanzania.
  • Vanderschelden B; Francis I. Proctor Foundation, University of California, San Francisco.
  • Oldenburg CE; Francis I. Proctor Foundation, University of California, San Francisco.
  • West SK; Francis I. Proctor Foundation, University of California, San Francisco.
  • Bailey RL; Francis I. Proctor Foundation, University of California, San Francisco.
  • Keenan JD; Francis I. Proctor Foundation, University of California, San Francisco.
  • Lietman TM; Francis I. Proctor Foundation, University of California, San Francisco.
Clin Infect Dis ; 68(12): 2114-2116, 2019 05 30.
Article em En | MEDLINE | ID: mdl-30561577
ABSTRACT
In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tracoma / Azitromicina / Mortalidade da Criança / Antibacterianos Tipo de estudo: Clinical_trials Limite: Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tracoma / Azitromicina / Mortalidade da Criança / Antibacterianos Tipo de estudo: Clinical_trials Limite: Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2019 Tipo de documento: Article