Synthesis, Characterization and inâvitro Studies of a Cathepsin B-Cleavable Prodrug of the VEGFR Inhibitor Sunitinib.

Karnthaler-Benbakka, Claudia; Koblmüller, Bettina; Mathuber, Marlene; Holste, Katharina; Berger, Walter; Heffeter, Petra; Kowol, Christian R; Keppler, Bernhard K

Synthesis, Characterization and inâvitro Studies of a Cathepsin B-Cleavable Prodrug of the VEGFR Inhibitor Sunitinib.

Karnthaler-Benbakka, Claudia; Koblmüller, Bettina; Mathuber, Marlene; Holste, Katharina; Berger, Walter; Heffeter, Petra; Kowol, Christian R; Keppler, Bernhard K.

Afiliação

Karnthaler-Benbakka C; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Straße 42, AT-1090, Wien.
Koblmüller B; Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8âA, AT-1090, Wien.
Mathuber M; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Straße 42, AT-1090, Wien.
Holste K; Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8âA, AT-1090, Wien.
Berger W; Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8âA, AT-1090, Wien.
Heffeter P; Research Cluster 'Translational Cancer Therapy Research', University of Vienna and Medical University of Vienna, AT-1090, Wien.
Kowol CR; Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8âA, AT-1090, Wien.
Keppler BK; Research Cluster 'Translational Cancer Therapy Research', University of Vienna and Medical University of Vienna, AT-1090, Wien.

Chem Biodivers ; 16(1): e1800520, 2019 Jan.

Article em En | MEDLINE | ID: mdl-30566287

Assuntos

Inibidores da Angiogênese/síntese química; Inibidores da Angiogênese/farmacologia; Catepsina B/metabolismo; Pró-Fármacos/síntese química; Pró-Fármacos/farmacologia; Receptores de Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores; Sunitinibe/síntese química; Sunitinibe/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Desenho de Fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Ativação Enzimática; Humanos; Técnicas In Vitro; Proteólise

Palavras-chave

cathepsin B; inhibitors; prodrugs; sunitinib; tyrosine kinase inhibitor; vascular endothelial growth factor receptor (VEGFR)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Catepsina B / Inibidores da Angiogênese / Receptores de Fatores de Crescimento do Endotélio Vascular / Sunitinibe Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article

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