A new isoflavone with anti-inflammatory effect from the seeds of Millettia pachycarpa.
Nat Prod Res
; 34(7): 981-987, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-30636441
ABSTRACT
A new isoflavone, milletenol A (1), along with four known flavonoids (2-5) were isolated from the seeds of Millettia pachycarpa. The structure of 1 was established by extensive spectroscopic methods while known compounds were identified by comparisons with literature data. Compound 1 and 2 showed significant anti-inflammatory activities against nitric oxide production in LPS-induced RAW264.7 macrophages. The state of CuSO4-stimulated inflammation was effectively alleviated by compound 1 in zebrafish. However, no significant cytotoxicity against human breast cancer cells was observed among all isolates.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sementes
/
Millettia
/
Isoflavonas
/
Anti-Inflamatórios
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China