Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain.
Neurology
; 92(7): e700-e709, 2019 02 12.
Article
em En
| MEDLINE
| ID: mdl-30651382
ABSTRACT
OBJECTIVE:
We aimed to examine whether impaired olfaction is associated with cognitive decline and indicators of neurodegeneration in the brain of dementia-free older adults.METHODS:
Within the Rush Memory and Aging Project, 380 dementia-free participants (mean age = 78 years) were followed for up to 15 years, and underwent MRI scans. Olfactory function was assessed using the Brief Smell Identification Test (B-SIT) at baseline, and categorized as anosmia (B-SIT <6), hyposmia (B-SIT 6-10 in men and 6-10.25 in women), and normal (B-SIT 10.25-12 in men and 10.5-12 in women). Cognitive function was annually assessed with a battery of 21 tests, from which composite scores were derived. Structural total and regional brain volumes were estimated. Data were analyzed using linear regression and mixed-effects models.RESULTS:
At study entry, 138 (36.3%) had normal olfactory function, 213 (56.1%) had hyposmia, and 29 (7.6%) had anosmia. In multiadjusted mixed-effects models, hyposmia (ß = -0.03, 95% confidence interval [CI] -0.05 to -0.02) and anosmia (ß = -0.13, 95% CI -0.16 to -0.09) were associated with faster rate of cognitive decline compared to normal olfaction. On MRI, impaired olfaction (hyposmia or anosmia) was related to smaller volumes of the hippocampus (ß = -0.19, 95% CI -0.33 to -0.05), and in the entorhinal (ß = -0.16, 95% CI -0.24 to -0.08), fusiform (ß = -0.45, 95% CI -0.78 to -0.14), and middle temporal (ß = -0.38, 95% CI -0.72 to -0.01) cortices.CONCLUSION:
Impaired olfaction predicts faster cognitive decline and might indicate neurodegeneration in the brain among dementia-free older adults.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Doenças Neurodegenerativas
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Disfunção Cognitiva
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Transtornos do Olfato
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Neurology
Ano de publicação:
2019
Tipo de documento:
Article