Could Dietary Glutamate Play a Role in Psychiatric Distress?
Neuropsychobiology
; 79(1): 13-19, 2020.
Article
em En
| MEDLINE
| ID: mdl-30699435
ABSTRACT
Glutamate is an amino acid that functions as an excitatory neurotransmitter. It has also been associated with somatic and psychiatric distress and is implicated in the pathophysiology of psychiatric disorders such as schizophrenia. Ingestion of dietary glutamate, such as monosodium glutamate (MSG), has been mechanistically linked with greater distress among patients with chronic pain conditions, though findings have been equivocal. Preliminary research suggests that an MSG-restricted diet confers beneficial effects on somatic symptoms and well-being for some individuals with chronic pain conditions. In addition to associations with somatic distress, glutamate has been associated with the onset and progression of psychiatric symptoms. Thus, the role of dietary glutamate in psychiatric distress represents an underdeveloped and potentially important area for future research aimed at clarifying pathophysiological mechanisms and identifying targets for dietary intervention in psychiatric illnesses.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sintomas Comportamentais
/
Fármacos Atuantes sobre Aminoácidos Excitatórios
/
Alimentos
/
Glutamatos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neuropsychobiology
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos