[Severe interstitial lung disease after one cycle of nivolumab treatment in a patient with advanced gastric cancer].
Nihon Shokakibyo Gakkai Zasshi
; 116(2): 153-160, 2019.
Article
em Ja
| MEDLINE
| ID: mdl-30745553
ABSTRACT
Although nivolumab was previously reported to cause immune-related interstitial lung diseases (ILD), the detailed characteristics of ILD in gastric cancer are not fully understood. We herein present a rare case of a 66-year-old male with advanced gastric cancer who experienced acute-onset high-grade fever and dyspnea and diagnosed with early-onset ILD during the first cycle of nivolumab. Computed tomography revealed patchy infiltrative shadows and ground-glass opacities. No pathological bacteria were detected in the sputum or the bronchoalveolar lavage, and serous antigens for virus and beta-D-glucan were below the detection limit. These findings were consistent with nivolumab-induced organizing pneumonia. The steroid pulse therapy was effective for ILD, and the patient had complete radiological response, although he relapsed twice during the steroid tapering period.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Doenças Pulmonares Intersticiais
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Antineoplásicos Imunológicos
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Nivolumabe
Limite:
Aged
/
Humans
/
Male
Idioma:
Ja
Revista:
Nihon Shokakibyo Gakkai Zasshi
Ano de publicação:
2019
Tipo de documento:
Article