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Osseointegration of titanium scaffolds manufactured by selective laser melting in rabbit femur defect model.
Ilea, Aranka; Vrabie, Oana-Gabriela; Babțan, Anida-Maria; Miclaus, Viorel; Ruxanda, Flavia; Sárközi, Melinda; Barbu-Tudoran, Lucian; Mager, Voicu; Berce, Cristian; Boșca, Bianca Adina; Petrescu, Nausica Bianca; Cadar, Oana; Câmpian, Radu Septimiu; Barabás, Réka.
Afiliação
  • Ilea A; Department of Oral Rehabilitation, Oral Health and Dental Office Management, Faculty of Dentistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Victor Babeș Str., no 15, Cluj-Napoca, Romania.
  • Vrabie OG; Faculty of Dentistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Victor Babeș Str., no 8, Cluj-Napoca, Romania.
  • Babțan AM; Department of Oral Rehabilitation, Oral Health and Dental Office Management, Faculty of Dentistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Victor Babeș Str., no 15, Cluj-Napoca, Romania.
  • Miclaus V; Department of Histology and Embriology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Manastur Avenue, no 3-5, Cluj-Napoca, Romania.
  • Ruxanda F; Department of Histology and Embriology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Manastur Avenue, no 3-5, Cluj-Napoca, Romania.
  • Sárközi M; Department of Chemistry and Chemical Engineering, Faculty of Chemistry and Chemical Engineering, Hungarian Line of Study, "Babes Bolyai" University Cluj-Napoca, Arany Janos Str., no 11, Cluj-Napoca, Romania.
  • Barbu-Tudoran L; Department of Molecular Biology and Biotechnology, Faculty of Biology, "Babes Bolyai" University Cluj-Napoca, Republicii (Gheorghe Bilașcu) Str., no 44, Cluj-Napoca, Romania.
  • Mager V; National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Donat Str., no 67-103, Cluj-Napoca, Romania.
  • Berce C; Postdoctorand of Technical University of Cluj-Napoca, Muncii Avenue, no103-105, Cluj-Napoca, Romania.
  • Boșca BA; Biobase Department of "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Str., no 6, Cluj-Napoca, Romania.
  • Petrescu NB; Department of Histology, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, Louis Pasteur Str., no 4, Cluj-Napoca, Romania. biancabosca@yahoo.com.
  • Cadar O; Department of Oral Rehabilitation, Oral Health and Dental Office Management, Faculty of Dentistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Victor Babeș Str., no 15, Cluj-Napoca, Romania.
  • Câmpian RS; INCDO-INOE 2000, Research Institute for Analytical Instrumentation, Cluj-Napoca, Donath Str., no 67, Cluj-Napoca, Romania.
  • Barabás R; Department of Oral Rehabilitation, Oral Health and Dental Office Management, Faculty of Dentistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Victor Babeș Str., no 15, Cluj-Napoca, Romania.
J Mater Sci Mater Med ; 30(2): 26, 2019 Feb 12.
Article em En | MEDLINE | ID: mdl-30747343
ABSTRACT
The aim of this study was to assess the osseointegration of two series of titanium (Ti) scaffolds with 0.8 and 1 mm cell size obtained by Selective Laser Melting (SLM) technique. One of the series had the Ti surface unmodified, while the other had the Ti surface coated with silicon-substituted nano-hydroxyapatite (nano-HapSi). The scaffolds were implanted in the femur bone defects of 6 White Californian male rabbits three animals were implanted with 0.8 mm cell size scaffolds and three animals with 1 mm cell size scaffolds, respectively. The bone fragments and scaffolds harvested at 2, 4 and 6 months were histologically analyzed using conventional light microscopy (LM) and scanning electron microscopy (SEM) for the qualitative evaluation of the bone tissue formed in contact with the scaffold. Both LM and SEM images indicated a better osseointegration for nano-HapSi coated Ti scaffolds. LM revealed that the compact bone formed in the proximity of nano-HapSi-coated scaffolds was better organized than spongy bone associated with unmodified scaffolds. Moreover, Ti scaffolds with meshes of 0.8 mm showed higher osseointegration compared with 1 mm. SEM images at 6 months revealed that the bone developed not only in contact with the scaffolds, but also proliferated inside the meshes. Nano-HapSi-coated Ti implants with 0.8 mm meshes were completely covered and filled with new bone. Ti scaffolds osseointegration depended on the mesh size and the surface properties. Due to the biocompatibility and favorable osseointegration in bone defects, nano-HapSi-coated Ti scaffolds could be useful for anatomical reconstructions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Titânio / Osseointegração / Alicerces Teciduais / Fêmur Tipo de estudo: Qualitative_research Limite: Animals Idioma: En Revista: J Mater Sci Mater Med Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Romênia
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Titânio / Osseointegração / Alicerces Teciduais / Fêmur Tipo de estudo: Qualitative_research Limite: Animals Idioma: En Revista: J Mater Sci Mater Med Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Romênia