Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines.

Ma, Xiaofeng; Hazelden, Ian R; Langer, Thomas; Munday, Rachel H; Bower, John F

Ma, Xiaofeng; Hazelden, Ian R; Langer, Thomas; Munday, Rachel H; Bower, John F.

Afiliação

Ma X; School of Chemistry , University of Bristol , Bristol , BS8 1TS , United Kingdom.
Hazelden IR; School of Chemistry , University of Bristol , Bristol , BS8 1TS , United Kingdom.
Langer T; Pharmaceutical Technology & Development , AstraZeneca , Charter Way , Macclesfield , SK10 2NA , United Kingdom.
Munday RH; Pharmaceutical Technology & Development , AstraZeneca , Charter Way , Macclesfield , SK10 2NA , United Kingdom.
Bower JF; School of Chemistry , University of Bristol , Bristol , BS8 1TS , United Kingdom.

J Am Chem Soc ; 141(8): 3356-3360, 2019 02 27.

Article em En | MEDLINE | ID: mdl-30775918

ABSTRACT

ABSTRACT

Pd(0)-systems modified with SPINOL-derived phosphoramidate ligands promote highly enantioselective aza-Heck cyclizations of alkenyl N-(tosyloxy)carbamates. The method provides versatile access to challenging N-heterocycles and represents the broadest scope enantioselective aza-Heck protocol developed to date.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Am Chem Soc Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

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