Enantioselective resolution of side-chain modified gem-difluorinated alcohols catalysed by Candida antarctica lipase B and monitored by capillary electrophoresis.

Pomeisl, Karel; Lamatová, Nikola; Solínová, Veronika; Pohl, Radek; Brabcová, Jana; Kasicka, Václav; Krecmerová, Marcela

Pomeisl, Karel; Lamatová, Nikola; Solínová, Veronika; Pohl, Radek; Brabcová, Jana; Kasicka, Václav; Krecmerová, Marcela.

Afiliação

Pomeisl K; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 542/2, 166 10 Prague 6, Czech Republic; Institute of Physics of the Czech Academy of Sciences, Na Slovance 1999/2, 182 21 Prague 8, Czech Republic.
Lamatová N; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 542/2, 166 10 Prague 6, Czech Republic; University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Solínová V; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 542/2, 166 10 Prague 6, Czech Republic.
Pohl R; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 542/2, 166 10 Prague 6, Czech Republic.
Brabcová J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 542/2, 166 10 Prague 6, Czech Republic.
Kasicka V; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 542/2, 166 10 Prague 6, Czech Republic. Electronic address: kasicka@uochb.cas.cz.
Krecmerová M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 542/2, 166 10 Prague 6, Czech Republic. Electronic address: marcela.krecmerova@uochb.cas.cz.

Bioorg Med Chem ; 27(7): 1246-1253, 2019 04 01.

Article em En | MEDLINE | ID: mdl-30777664

Assuntos

Proteínas Fúngicas/metabolismo; Lipase/metabolismo; Biocatálise; Eletroforese Capilar; Estrutura Molecular; Estereoisomerismo; Termodinâmica

Palavras-chave

Acyclic nucleoside phosphonates; Candida antarctica lipase; Capillary electrophoresis; Enantioselective resolution; Enzyme catalysis; Gem-difluorinated alcohols; Isomerisation; Transesterification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Fúngicas / Lipase Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: República Tcheca

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