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Whitening effect of L-ascorbate-2-phosphate trisodium salt on solar lentigos.
Ishikawa, Yuko; Niwano, Takao; Hirano, Shinichi; Numano, Kayoko; Takasima, Kazunori; Imokawa, Genji.
Afiliação
  • Ishikawa Y; ToutVert Co. Ltd, Osaka, Japan.
  • Niwano T; Center for Bioscience Research and Education, Utsunomiya University, 350 Mine Utsunomiya, Tochigi, 321-8505, Japan.
  • Hirano S; ToutVert Co. Ltd, Osaka, Japan.
  • Numano K; Quines Square Dermatological Clinic, Kanagawa, Japan.
  • Takasima K; Ebisu Skin Research Center, Inforward Co. LTD, Tokyo, Japan.
  • Imokawa G; Center for Bioscience Research and Education, Utsunomiya University, 350 Mine Utsunomiya, Tochigi, 321-8505, Japan. imokawag@dream.ocn.ne.jp.
Arch Dermatol Res ; 311(3): 183-191, 2019 Apr.
Article em En | MEDLINE | ID: mdl-30778667
ABSTRACT
Little is known about the anti-pigmenting effects of whitening agents on solar lentigos (SLs), which comprise ~ 60% of hyperpigmented facial lesions of Asian subjects. Lotions with or without 6% L-ascorbate-2-phosphate trisodium salt (APS) [test lotion (TL) and placebo lotion (PL), respectively] were applied twice daily for 24 weeks in a double-blind half-face study of 27 Japanese females with SLs on both sides of their faces. Pigmentation scores were evaluated using a photo-scale and the skin colors were assessed using a color difference meter and a mexameter for SLs and the non-lesional surrounding skin (NLS). Although the pigmentation scores were not significantly different between the TL and PL-treated SLs after 24 weeks, the L values of TL-treated SLs and NLS increased significantly with a significantly higher △L value in SLs than in NLS. In contrast, the L values of PL-treated SLs and NLS remained unchanged after the treatment. The number of subjects with > 2.0 △L was 7 of 27 (TL) and 0 of 27 (PL) in SLs and 3 of 27 (TL) and 0 of 27 (PS) in NLS. In contrast, the melanin index in TL-treated SLs and NLS significantly decreased with a significantly higher △melanin index in SLs than in NLS. Similarly, the melanin index of PL-treated SLs and NLS were significantly decreased with a significantly higher △melanin index in SLs than in NLS. These findings strongly indicate that APS has a weak but significant anti-pigmenting effect on SLs and a significant whitening effect even on normally pigmented healthy skin.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Pigmentação da Pele / Preparações Clareadoras de Pele / Lentigo / Melaninas / Melanócitos Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Female / Humans País/Região como assunto: Asia Idioma: En Revista: Arch Dermatol Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Pigmentação da Pele / Preparações Clareadoras de Pele / Lentigo / Melaninas / Melanócitos Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Female / Humans País/Região como assunto: Asia Idioma: En Revista: Arch Dermatol Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão