Transgenerational inheritance of cold temperature response in Drosophila.
FEBS Lett
; 593(6): 594-600, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30779346
ABSTRACT
Intergenerational inheritance of transcriptional responses induced by low temperature rearing has recently been shown in Drosophila. Besides germline inheritance, fecal transfer experiments indirectly suggested that the acquired microbiome may also have contributed to the transcriptional responses in offspring. Here, we analyze expression data on inheritance of the cold-induced effects in conjunction with previously reported transcriptomic differences between flies with a microbiota or axenic flies and provide support for a contribution of the acquired microbiome to the offspring phenotype. Also, based on a similar analysis in conjunction with diet- and metabolism-related fly transcriptome data, we predicted and, then, experimentally confirmed that cold regulates triglyceride levels both inter- as well as trans-generationally.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triglicerídeos
/
Adaptação Fisiológica
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Genes de Insetos
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Padrões de Herança
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Epigênese Genética
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Drosophila melanogaster
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Índia