Genetic suppression of IKK2/NF-&#954;B in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease.

Kirkley, Kelly S; Popichak, Katriana A; Hammond, Sean L; Davies, Cecilia; Hunt, Lindsay; Tjalkens, Ronald B

Genetic suppression of IKK2/NF-κB in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease.

Kirkley, Kelly S; Popichak, Katriana A; Hammond, Sean L; Davies, Cecilia; Hunt, Lindsay; Tjalkens, Ronald B.

Afiliação

Kirkley KS; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523.
Popichak KA; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523.
Hammond SL; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523.
Davies C; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523.
Hunt L; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523.
Tjalkens RB; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA 80523; Program in Molecular, Cellular and Integrative Neuroscience, Colorado State University, Fort Collins, CO, USA 80523. Electronic address: Ron.Tjalkens@colostate.edu.

Neurobiol Dis ; 127: 193-209, 2019 07.

Article em En | MEDLINE | ID: mdl-30818064

Assuntos

Astrócitos/metabolismo; Neurônios Dopaminérgicos/metabolismo; Quinase I-kappa B/metabolismo; Intoxicação por MPTP/metabolismo; NF-kappa B/metabolismo; Animais; Morte Celular/fisiologia; Neurônios Dopaminérgicos/patologia; Quinase I-kappa B/genética; Intoxicação por MPTP/patologia; Masculino; Camundongos; Camundongos Knockout; NF-kappa B/genética; Probenecid; Substância Negra/metabolismo; Substância Negra/patologia

Palavras-chave

Astrocytes; IKK2; MPTP; NFκB; Neuroinflammation; Transgenic models

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrócitos / NF-kappa B / Intoxicação por MPTP / Quinase I-kappa B / Neurônios Dopaminérgicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article

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