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Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.
Takashita, Emi; Kawakami, Chiharu; Ogawa, Rie; Morita, Hiroko; Fujisaki, Seiichiro; Shirakura, Masayuki; Miura, Hideka; Nakamura, Kazuya; Kishida, Noriko; Kuwahara, Tomoko; Ota, Akira; Togashi, Hayato; Saito, Ayako; Mitamura, Keiko; Abe, Takashi; Ichikawa, Masataka; Yamazaki, Masahiko; Watanabe, Shinji; Odagiri, Takato.
Afiliação
  • Takashita E; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Kawakami C; Yokohama City Institute of Public Health, Kanagawa, Japan.
  • Ogawa R; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Morita H; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Fujisaki S; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Shirakura M; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Miura H; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Nakamura K; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Kishida N; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Kuwahara T; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Ota A; Saiseikai Yokohamashi Nanbu Hospital, Kanagawa, Japan.
  • Togashi H; Saiseikai Yokohamashi Nanbu Hospital, Kanagawa, Japan.
  • Saito A; Saito Children's Clinic, Kanagawa, Japan.
  • Mitamura K; Eiju General Hospital, Tokyo, Japan.
  • Abe T; Abe Children's Clinic, Kanagawa, Japan.
  • Ichikawa M; Ichikawa Children's Clinic, Kanagawa, Japan.
  • Yamazaki M; Zama Children's Clinic, Kanagawa, Japan.
  • Watanabe S; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
  • Odagiri T; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
Euro Surveill ; 24(12)2019 Mar.
Article em En | MEDLINE | ID: mdl-30914078
ABSTRACT
In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited reduced susceptibility to baloxavir but were susceptible to neuraminidase inhibitors. Only one of the two children had been treated with baloxavir. An epidemiological analysis suggests possible transmission of the PA I38T mutant A(H3N2) virus among humans.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Oxazinas / Piridinas / Tiepinas / Triazinas / Farmacorresistência Viral / Influenza Humana / Vírus da Influenza A Subtipo H3N2 Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Child / Humans / Middle aged País/Região como assunto: Asia Idioma: En Revista: Euro Surveill Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Oxazinas / Piridinas / Tiepinas / Triazinas / Farmacorresistência Viral / Influenza Humana / Vírus da Influenza A Subtipo H3N2 Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Child / Humans / Middle aged País/Região como assunto: Asia Idioma: En Revista: Euro Surveill Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão