Chemosensitizer effect of cisplatin-treated bladder cancer cells by phenazine-5,10-dioxides.
Environ Toxicol Pharmacol
; 69: 9-15, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-30921672
ABSTRACT
We determined the chemosensitizer effect of phenazine dioxide derivatives to cisplatin and the possible mechanism of action on bladder cancer cells. Anti-proliferative activity of nine phenazine dioxide derivatives in presence or absence of cisplatin was evaluated in two bladder tumor human cells T24 and 253 J and one non tumor cell line V79-4. The sensitizer effect of the combined treatment was determined by chromosomal aberrations and micronucleus test. A possible mechanism of action of the sensitizer compounds as HDACi was also investigated.The phenazine dioxide 2c combined with cisplatin induced a cell cycle arrest on bladder cancer cells and resensitize the invasive and cisplatin resistant 253 J cell line. The HDAC inhibitory activity appears as one of the mechanism of action of the compound. The low toxicity levels against normal cells point out the phenazine dioxide derivative 2c as a very good scaffold for further design of HDACi sensitizer agents.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenazinas
/
Cisplatino
/
Inibidores de Histona Desacetilases
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Ano de publicação:
2019
Tipo de documento:
Article