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Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
Harris, Philip A; Faucher, Nicolas; George, Nicolas; Eidam, Patrick M; King, Bryan W; White, Gemma V; Anderson, Niall A; Bandyopadhyay, Deepak; Beal, Allison M; Beneton, Veronique; Berger, Scott B; Campobasso, Nino; Campos, Sebastien; Capriotti, Carol A; Cox, Julie A; Daugan, Alain; Donche, Frederic; Fouchet, Marie-Hélène; Finger, Joshua N; Geddes, Brad; Gough, Peter J; Grondin, Pascal; Hoffman, Bonnie L; Hoffman, Sandra J; Hutchinson, Susan E; Jeong, Jae U; Jigorel, Emilie; Lamoureux, Pauline; Leister, Lara K; Lich, John D; Mahajan, Mukesh K; Meslamani, Jamel; Mosley, Julie E; Nagilla, Rakesh; Nassau, Pamela M; Ng, Sze-Ling; Ouellette, Michael T; Pasikanti, Kishore K; Potvain, Florent; Reilly, Michael A; Rivera, Elizabeth J; Sautet, Stéphane; Schaeffer, Michelle C; Sehon, Clark A; Sun, Helen; Thorpe, James H; Totoritis, Rachel D; Ward, Paris; Wellaway, Natalie; Wisnoski, David D.
Afiliação
  • Faucher N; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France.
  • George N; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France.
  • White GV; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Anderson NA; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Beneton V; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France.
  • Campos S; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Daugan A; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France.
  • Donche F; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France.
  • Fouchet MH; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France.
  • Grondin P; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France.
  • Hutchinson SE; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Jigorel E; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France.
  • Lamoureux P; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France.
  • Mosley JE; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Nassau PM; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Potvain F; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France.
  • Sautet S; Flexible Discovery Unit , GlaxoSmithKline , 25-27 avenue du Québec , 91951 Les Ulis Cedex , France.
  • Thorpe JH; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
  • Wellaway N; Flexible Discovery Unit , GlaxoSmithKline , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.
J Med Chem ; 62(10): 5096-5110, 2019 05 23.
Article em En | MEDLINE | ID: mdl-31013427
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Proteínas de Ligação a RNA / Complexo de Proteínas Formadoras de Poros Nucleares / Inibidores Enzimáticos Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Proteínas de Ligação a RNA / Complexo de Proteínas Formadoras de Poros Nucleares / Inibidores Enzimáticos Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article