[The inhibition effects of apatinib on cell proliferation, migration and apoptosis in esophageal carcinoma via Ras/Raf/MEK/ERK and JAK2/STAT3 pathways].

Feng, Y; Zhou, M Y; Sun, F; Kong, Z; Wang, J; Sun, Z Q; Hu, L J; Wang, J L; Hua, Q; Yu, J P

Feng, Y; Zhou, M Y; Sun, F; Kong, Z; Wang, J; Sun, Z Q; Hu, L J; Wang, J L; Hua, Q; Yu, J P.

Afiliação

Feng Y; Department of Radiotherapy, Zhoushan Branch of Shanghai Ruijin Hospital, Zhoushan 316011, China.
Zhou MY; Department of Radiotherapy and Oncology, Changzhou No.2 People's Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China.
Sun F; Department of Radiotherapy and Oncology, Changzhou No.2 People's Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China.
Kong Z; Department of Radiotherapy and Oncology, Changzhou No.2 People's Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China.
Wang J; Department of Radiotherapy and Oncology, Changzhou No.2 People's Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China.
Sun ZQ; Department of Radiotherapy and Oncology, Changzhou No.2 People's Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China.
Hu LJ; Department of Radiotherapy and Oncology, Changzhou No.2 People's Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China.
Wang JL; Department of Radiotherapy and Oncology, Changzhou No.2 People's Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China.
Hua Q; Department of Radiotherapy and Oncology, Changzhou No.2 People's Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China.
Yu JP; Department of Radiotherapy and Oncology, Changzhou No.2 People's Hospital, the Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China.

Zhonghua Zhong Liu Za Zhi ; 41(4): 263-275, 2019 Apr 23.

Article em Zh | MEDLINE | ID: mdl-31014051

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Neoplasias Esofágicas/tratamento farmacológico; Carcinoma de Células Escamosas do Esôfago/tratamento farmacológico; Piridinas/farmacologia; Animais; Linhagem Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Neoplasias Esofágicas/metabolismo; Neoplasias Esofágicas/patologia; Carcinoma de Células Escamosas do Esôfago/metabolismo; Carcinoma de Células Escamosas do Esôfago/patologia; Xenoenxertos; Janus Quinase 2/metabolismo; MAP Quinase Quinase Quinases/metabolismo; Sistema de Sinalização das MAP Quinases; Camundongos; Camundongos Nus; Distribuição Aleatória; Fator de Transcrição STAT3/metabolismo; Transdução de Sinais; Fator A de Crescimento do Endotélio Vascular/metabolismo; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

Apatinib; Apoptosis; Esophageal neoplasms; Nude mice; Vascular endothelial growth factor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Neoplasias Esofágicas / Movimento Celular / Apoptose / Proliferação de Células / Carcinoma de Células Escamosas do Esôfago / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: Zh Revista: Zhonghua Zhong Liu Za Zhi Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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