Early smoking-onset age and risk of cardiovascular disease and mortality.
Prev Med
; 124: 17-22, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31054906
ABSTRACT
Early smoking onset age (SOA) is a public health concern with scant empirical evidence of its role in health outcomes. The study had two aims:
i) to assess whether an early SOA was associated with the risk of fatal and non-fatal CVD and all-cause and CVD mortality and ii) to explore the linear and non-linear association between SOA and the outcomes of interest. Data from 4499 current or former smokers, recruited from 1995 to 2005, aged 25 to 79â¯years, and with a median 7.02â¯years of follow-up, were obtained from the REGICOR population-based cohort. In the present analysis, performed in 2018, the independent variable was SOA and the dependent variables were CVD events, CVD mortality, and all-cause mortality. Penalized smoothing spline methods were used to assess the linear and non-linear association. During follow-up, 361 deaths and 210 CVD events were recorded. A significant non-linear component was identified in the association between SOA and CVD outcomes with a cut-off point at 12â¯years In the group aged ≤12â¯years, each year of delay in SOA was inversely associated with CVD risk (HRâ¯=â¯0.71; 95%CIâ¯=â¯0.53-0.96) and CVD mortality (HRâ¯=â¯0.58; 95%CIâ¯=â¯0.37-0.90). No association was observed in the older SOA group. A linear association was observed between SOA and all-cause mortality, and each year of delay was associated with 4% lower risk of mortality (HRâ¯=â¯0.96; 95%CIâ¯=â¯0.93-0.98). The associations were adjusted for lifelong exposure to tobacco and cardiovascular risk factors. These results reinforce the value of preventing tobacco use among teenagers and adolescents.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Fumar
/
Idade de Início
Tipo de estudo:
Etiology_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Prev Med
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Espanha