N-Pyrazoloyl and N-thiopheneacetyl hydrazone of isatin exhibited potent anti-inflammatory and anti-nociceptive properties through suppression of NF-&#954;B, MAPK and oxidative stress signaling in animal models of inflammation.

Zeeshan, Sara; Naveed, Muhammad; Khan, Adnan; Atiq, Ayesha; Arif, Maryam; Ahmed, Muhammad Naeem; Kim, Yeong Shik; Khan, Salman

N-Pyrazoloyl and N-thiopheneacetyl hydrazone of isatin exhibited potent anti-inflammatory and anti-nociceptive properties through suppression of NF-κB, MAPK and oxidative stress signaling in animal models of inflammation.

Zeeshan, Sara; Naveed, Muhammad; Khan, Adnan; Atiq, Ayesha; Arif, Maryam; Ahmed, Muhammad Naeem; Kim, Yeong Shik; Khan, Salman.

Afiliação

Zeeshan S; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Naveed M; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Khan A; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Atiq A; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Arif M; Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
Ahmed MN; Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
Kim YS; College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea.
Khan S; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. skhan@qau.edu.pk.

Inflamm Res ; 68(7): 613-632, 2019 Jul.

Article em En | MEDLINE | ID: mdl-31079165

Assuntos

Analgésicos/uso terapêutico; Anti-Inflamatórios/uso terapêutico; Edema/tratamento farmacológico; Hidrazonas/uso terapêutico; Hiperalgesia/tratamento farmacológico; Isatina; Analgésicos/farmacologia; Animais; Anti-Inflamatórios/farmacologia; Citocinas/imunologia; Modelos Animais de Doenças; Edema/imunologia; Temperatura Alta/efeitos adversos; Hidrazonas/farmacologia; Hiperalgesia/imunologia; Masculino; Camundongos Endogâmicos BALB C; Proteínas Quinases Ativadas por Mitógeno/imunologia; NF-kappa B/imunologia; Estresse Oxidativo/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Estômago/efeitos dos fármacos

Palavras-chave

Allodynia; CFA; Hydrazide derivatives; Hyperalgesia; Inflammatory pain; Isatin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Edema / Hidrazonas / Hiperalgesia / Analgésicos / Isatina / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Inflamm Res Assunto da revista: ALERGIA E IMUNOLOGIA / PATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Paquistão

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