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Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK/ERK signal pathway.
Zhang, Shi-Lan; Zhu, Hong-Yi; Zhou, Bing-Yi; Chu, Yi; Huo, Ji-Rong; Tan, Yu-Yong; Liu, De-Liang.
Afiliação
  • Zhang SL; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.
  • Zhu HY; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.
  • Zhou BY; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.
  • Chu Y; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.
  • Huo JR; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.
  • Tan YY; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.
  • Liu DL; Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.
Onco Targets Ther ; 12: 2409-2419, 2019.
Article em En | MEDLINE | ID: mdl-31118659
ABSTRACT

Purpose:

To investigate the expression of histone deacetylase 6 (HDAC6) in colon cancer and its role in colon cancer cell growth and migration. Materials and

methods:

We detected the expression of HDAC6 in a colon cancer tissue chip using immunochemical staining, and analyzed the difference in HDAC6 expression between cancer and adjacent noncancerous tissues. Then, we explored the relationship between HDAC6 expression and patients' clinicopathological characteristics and prognoses. In adidition, the role of HDAC6 in colon cancer cell growth and migration, as well as its potential related signal pathway, through HDAC6 knockdown was explored.

Results:

The immunochemical score of HDAC6 expression was higher in cancer tissue than in the adjacent noncancerous tissue (4.54 vs 3.08, P<0.005); similarly, as well as the rate of high HDAC6 expression was higher in cancer tissue than in the adjacent noncancerous tissue (71.1% vs 40.9%, P<0.001). Patients showing high HDAC6 expression had a shorter overall survival time. Additionally, Cox regression analysis showed that high HDAC6 expression was an independent risk factor for poor prognosis. HDAC6 knockdown decreased cell viability, colony formation, and number of migrated colon cancer cells (HCT116 and HT29); the expression of p-MEK, p-ERK, and p-AKT was also decreased, but had no influence on MEK, ERK, and AKT expression.

Conclusion:

HDAC6 is highly expressed in colon cancer and associated with a poor prognosis. HDAC6 knockdown inhibits colon cancer cell growth and migration, partly through the MAPK/ERK pathway.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Onco Targets Ther Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Onco Targets Ther Ano de publicação: 2019 Tipo de documento: Article